Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.
PMID: 30804200ĭeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. The mechanosensitive ion channel Piezo inhibits axon regeneration. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN.
Preview for “Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin”, same issue. Casein Kinase 1δ Triggers Giant Ankyrin Expression.
Bio sci uci peer tutoring software#
Comparing automated morphology quantification software on dendrites of uninjured and injured Drosophila neurons. These challenges are significantly exacerbated when neurons in aging animals attempt to recover from injury.Ĭurrent and future projects will deepen our knowledge about dendrite regeneration to create a new framework for understanding how neurons recover from injury in both young and aging animals. Moreover, there are mechanistic differences between the outgrowth of uninjured neurons versus the regeneration of dendrites after injury: dendrite regeneration is uniquely dependent on neuronal activity, ignores cues that constrain and pattern normal dendrite outgrowth, and confronts a mature tissue environment that is different from what a developing neuron would encounter. We have observed that after injury, neurons regrow dendrites that recreate some features of uninjured dendrites, but are unable to reconstruct an entire arbor that perfectly mimics an uninjured neuron. Our previous work found that the sensory neurons in the fruit fly Drosophila peripheral nervous system exhibit robust regeneration of dendrites after injury and used this system to explore central features of dendrite regeneration in developing animals, young adults, and aging adults. Our long term research goal is to understand the cellular mechanisms of dendrite regeneration after injury. Dendrites can be injured by traumatic brain injury, stroke, and many forms of neurodegeneration, yet while the factors that control axon regeneration after injury have been extensively studied, we know almost nothing about dendrite regeneration. The Thompson-Peer lab explores how neurons recover from injury in vivo, and how this process is similar to and different from normal development.Īt the most fundamental level, a neuron receives information along dendrites, and sends information down an axon to synaptic contacts. Investigating how neurons respond and recover after injury
0 kommentar(er)
